| Time | Matchup | Prediction | Actual | Result |
|---|
| 9/17/2021 7:30 PM |  UCF @ Louisville 
by 7 | UCF wins 41.4-14.1 won 93.85% of sims, average margin of 27.2
| Louisville wins 42-35
|  |
| 9/25/2021 3:30 PM | Louisville @ Florida State 
by 1.5 | Florida State wins 28.8-21.4 won 68.61% of sims, average margin of 7.3
| Louisville wins 31-23
| |
| 10/2/2021 12:30 PM | Louisville @ Wake Forest 
by 7 | Wake Forest wins 31.0-20.2 won 73.56% of sims, average margin of 10.7
| Wake Forest wins 37-34
|  |
| 10/9/2021 3 PM |  Virginia @ Louisville
by 2.5 | Virginia wins 42.2-17.2 won 93.13% of sims, average margin of 25.0
| Virginia wins 34-33
|  |
| 10/23/2021 4 PM |  Boston College @ Louisville
by 6 | Louisville wins 30.6-20.5 won 72.07% of sims, average margin of 10.1
| Louisville wins 28-14
|  |
| 10/30/2021 7:30 PM | Louisville @ NC State 
by 6.5 | Louisville wins 27.9-20.7 won 66.42% of sims, average margin of 7.2
| NC State wins 28-13
| |
| 11/6/2021 6:30 PM |  Clemson (20) @ Louisville
by 4.5 | Louisville wins 24.2-18.2 won 65.45% of sims, average margin of 6.0
| Clemson wins 30-24
| |
| 11/13/2021 12 PM |  Syracuse @ Louisville
by 3 | Syracuse wins 21.8-19.9 won 57.27% of sims, average margin of 1.8
| Louisville wins 41-3
| |
| 11/18/2021 7:30 PM | Louisville @ Duke 
by 20 | Louisville wins 41.5-13.6 won 93.88% of sims, average margin of 27.9
| Louisville wins 62-22
| |
| 11/27/2021 7:30 PM |  Kentucky @ Louisville
by 2.5 | Louisville wins 31.3-23.9 won 67.56% of sims, average margin of 7.4
| Kentucky wins 52-21
| |
| 12/28/2021 3:15 PM |  Air Force @ Louisville
by 1 | Louisville wins 35.6-16.3 won 88.75% of sims, average margin of 19.2
| Air Force wins 31-28
| |
